Lipogenesis: a pathway of hydrogen release

Generally, de novo synthesis of fatty acids is strongly upregulated in tumor cells.

Fatty acids are an efficient hydrogen store. Under hypoxic conditions, the release of fatty acids is an effective way to get rid of surplus hydrogen.

The acetyl-CoA can derive from the degradation of glucose or ketone bodies.

In xeno-transplanted tumors a strong correlation can be observed between glucose consumption and fatty acid release.