The expression tumor metabolome takes into account the fact that different tissues with totally different basic metabolism, such as liver and brain, generally shift to the same metabolic phenotype during tumorigenesis.
The tumor metabolome:
The tumor metabolome is characterized by:
- High glycolytic enzyme activities
- The expression of the pyruvate kinase isoenzyme type M2
- High phosphometabolite levels
- A high channelling of glucose carbons to synthetic processes
A high rate of pyrimidine and purine de novo synthesis
- A high rate of fatty acid de novo synthesis
- A low (ATP+GPT) : (CTP+UTP) ratio
- Low AMP levels
- A high glutaminolytic capacity
- Release of immunosuppressive metabolites
A high methionine dependency